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S. Amuthalakshmi, M.Pharm., Ph.D (Pharmaceutical Chemistry)
Associate Professor
Department of Pharmaceutical Chemistry
- Email.id : amuthaaris@gmail.com
- Contact: 044 – 24960151
Overview
Dr. S. Amuthalakshmi is an experienced academician and researcher with over 19 years of teaching and research experience in pharmaceutical sciences, particularly in medicinal chemistry, drug design, and pharmaceutical analysis. She has served in reputed pharmacy institutions across India, currently working as an Associate Professor at C.L. Baid Metha College of Pharmacy, Chennai since August 2014.
She possesses a strong academic foundation in pharmaceutical sciences with progressive specialization in medicinal chemistry and research. She earned her Ph.D. in Pharmacy (Full-Time) from Annamalai University, India (2010–2014), where she focused on advanced pharmaceutical research and scholarly investigations.
Earlier, she completed her Master of Pharmacy (M.Pharm) in Medicinal Chemistry with First Class from M.S. University of Baroda, India (2002–2004), gaining strong expertise in drug design, synthesis, and analytical techniques.
She began her professional academic journey with a Bachelor of Pharmacy (B.Pharm) degree, graduating with First Class from Dr. M.G.R. Medical University, India (1995–1999), which provided a comprehensive foundation in pharmaceutical sciences.
Throughout her career, she has taught a wide range of subjects including Medicinal chemistry, Synthetic organic chemistry, Pharmaceutical Inorganic Chemistry, Natural product chemistry, Physicochemical principles, Molecular modeling, Computer Aided Drug Design and drug design to B.Pharm, M.Pharm, and Pharm.D students. She has also guided numerous undergraduate and postgraduate research projects and actively contributes to curriculum development, academic evaluation, and research mentoring.Her research focuses on rational drug design, QSAR studies, molecular modeling, and the development of novel therapeutic agents for diseases such as Alzheimer’s disease and diabetes. She has published multiple research and review articles in national and international journals, received a research grant from The Tamil Nadu Dr. M.G.R. Medical University, and holds an Indian patent.In addition to teaching and research, she actively participates in academic administration, peer review of scientific manuscripts, conference organization, and scholarly activities, contributing significantly to pharmaceutical education and research advancement. Received a Theme Based Research (TBR) Grant for April-June 2024 from The TNMGR Medical university by July 2024 in the title of “AI-Driven Virtual Screening: Uncovering novel poly pharmacological ligands targeting Alzheimer’s disease via Flavone-acridine/piperidine scaffolds” for 2 Lakh rupees.
B.Pharm Projects Guided -15m.Pharm Projects Guided -18.
Google Scholar Link: https://scholar.google.com/citations?user=Q7JG7pQAAAAJ&hl=en
Scopus Author ID: 55333491900
Total Citations (Google Scholar): 290
H-index (Google Scholar) : 9
1. Pradeep Natarajan*, Amuthalakshmi Sivaperuman, Ramalakshmi Natarajan, Nalini Calambur Nagarajan; Natural Products and Breast Cancer: Targeting Crucial Signaling Pathways, Journal of Pharmaceutical Sciences, 1,10, 634-655, ISSN: 1520-6017, 2025.
2. Prabakaran A, Sivaperuman A, Natarajan R, Nagarajan NC, Solomon VR. Innovative Approaches to Alzheimer’s Treatment: Utilizing Tacrine Hybrids to Inhibit Amyloid Beta Aggregation as a Strategic Focus. Mini Rev Med Chem. 2026 Jan 7. doi: 10.2174/0113895575422492251116190843. Epub ahead of print. PMID: 41510718.
3. Ramalakshmi N Dibenthiran S, Arunkumar S , Amuthalakshmi S , Indrakumar S , Nalini Cn A Comprehensive Review on Flavone Scaffolds: Examining their Structural Modifications and Biological Activities. Curr Top Med Chem. Volume 26, Issue , Year 2026
4. Prabakaran, A; Sivaperuman, Amuthalakshmi; Natarajan, Ramalakshmi; Nagarajan, Nalini Calambur; Nachiappan, Dhatchana Moorthy; Solomon, Viswas Raja; Computational investigation and synthesis of 6-chlorocoumarin-oxadiazole hybrids for identifying newer candidates against Alzheimer’s disease using multi-target strategies, Computational investigation and synthesis of 6-chlorocoumarin-oxadiazole hybrids for identifying newer candidates against Alzheimer’s disease using multi-target strategies, 100260, 2026, Elsevier
5. Sivaperuman A, Narayanasamy K, Nagarajan NC, Natarajan R, Nachiappan DM, Kalpana S. From bench to byte: small molecule development for Alzheimer’s disease in the AI era. 2025;15(5):1309-27.
6. Natarajan R, Kumar P, Subramani A, Sivaperuman A, Angamuthu P, Bhandare RR, Shaik AB. A critical review on therapeutic potential of benzimidazole derivatives: a privileged scaffold. Med Chem. 2024;20:311-51.
7. Ravi R, Sivaperuman A, Annadurai S, Natarajan R. Coumarin derivatives as potential antibacterial agents and SAR relationship against gram-negative Escherichia coli: mechanism and future prospects. J Pharm Qual Assur Qual Control. 2024;6(2):421.
8. Sivaperuman A, Natarajan R, Ravi R, Subramanian A, Angamuthu P. Coumarin: a renowned moiety for gram-negative Escherichia coli – a review. Pharm Chem J. 2023;57(8):1183-93.
9. Natarajan R, Sivaperuman A, Samuel A, Patel DH, Jain N, Veerappan M, Kumar NK. 2D QSAR, design, and in silico analysis of thiophene-tethered lactam derivatives as antimicrobial agents. Chem Biodivers. 2023;20(7):e202300331.
10. Menaka S, Sivaperuman A, Natarajan R, Dhinakaran K. A unique perspective on lead compounds for dementia with Lewy body. Med Chem. 2023;19(10):946-59.
11. Sivaperuman A, Natarajan R, Ravi R, Subramanian A, Angamuthu P. Coumarin: a renowned moiety for gram-negative Escherichia coli – a review. Pharm Chem J. 2023;57(8):1183-93.
12. Sivaperuman A, Nalini CN, Sindhuja S. A review on PCR and POC-PCR – a boon in the diagnosis of COVID-19. Curr Pharm Anal. 2022;18(8).
13. Subramani A, Sivaperuman A, Natarajan R, Bhandare RR, Shaik AB. QSAR and molecular docking studies of pyrimidine–coumarin–triazole conjugates as prospective anti-breast cancer agents. Molecules. 2022;27.
14. Subramani A, Angamuthu P, Sivaperuman A, Natarajan R. Design, synthesis, docking, characterization and biological screening of novel azetidinone derivatives of nicotinic acid. Curr Bioact Compd. 2022;18(3).
15. Natarajan R, Amuthalakshmi S, Yamuna R, Smith AA, Arunkumar. Indolizine – a privileged biological scaffold. Der Pharm Chem. 2021;13(2).
16. Sivaperuman A, Nagarajan NC, Jayapaul U. Simultaneous RP-HPLC estimation and validation of metronidazole, furazolidone, and dicyclomine in capsule. J Rep Pharm Sci. 2021;10(1).
17. Nagarajan NC, Sivaperuman A, Priya. Stability indicating RP-HPLC simultaneous estimation of hyoscine butylbromide and paracetamol in tablets. Pharm Chem J. 2021;55(4).
18. Ramalakshmi N, Amuthalakshmi S, Arunkumar S. Role of different drug likeness filters in drug design. World J Pharm Pharm Sci. 2021;10(2).
19. Helina N, Natarajan R, Yuvarani K, Amuthalakshmi S. PROTAC technology in cancer drug development – a review. Int J All Res Educ Sci Methods. 2021;9(2).
20. Sundari J, Amuthalakshmi S, Nalini CN. Review on analytical methods for quantification of ADHD drugs in human biological samples. Rev Anal Chem. 2020;39:130-56.
21. Devaraj S, Sivaperuman A, Nagarajan NC. RP-UPLC method development and validation for simultaneous estimation of mometasone furoate and miconazole nitrate in semisolid dosage form. Acta Pharm Sci. 2020;58(3).
22. Nalini CN, Rajesh K, Amuthalakshmi S. Heterocyclic derivatives: easy three-component microwave assisted synthesis, and anticonvulsant, anti-inflammatory evaluation. Curr Microwave Chem. 2018;5:189-97.
23. Nalini CN, Rajesh K, Amuthalakshmi S. Method development and validation of naproxen sodium in pharmaceutical tablet dosage form by RP-HPLC. World J Pharm Pharm Sci. 2018;7(2):790-6.
24. Krishna VR, Amuthalakshmi S, Nalini CN. Validation of a stability-indicating reverse phase HPLC method for determination of canagliflozin. World J Pharm Res. 2017;7(3):459-68.
25. Mustafa M, Amuthalakshmi S, Nalini CN. Simultaneous UPLC estimation of fexofenadine HCl and montelukast sodium tablets. Res J Pharm Tech. 2017;10(2):559-62.
26. Amuthalakshmi S, Anton Smith A. In silico design of pyrazole derivatives as DPP IV inhibitors. Int J Pharm Pharm Sci. 2013;5(4).
27. Sivaperuman A, Anton Smith A. In silico design of piperazinone derivatives as DPP IV inhibitors in type II diabetes mellitus. Middle East J Sci Res. 2013;16(5):580-6.
28. Amuthalakshmi S, Anton Smith A. In silico design of a ligand for DPP IV in type II diabetes. Adv Biol Res. 2013;7(6):248-52
29. Amuthalakshmi S, Anton Smith A, Manavalan R. Modeling-assisted in silico design of ligand molecule for DPP IV in type II diabetes mellitus. Lett Drug Des Discov. 2012;9:764-6.
30. Patel SKN, Anton Smith A, Amuthalakshmi S, Gandhi VN, Manavalan R. Analytical method development and validation of ofloxacin eye drop by HPLC. J Curr Chem Pharm Sci. 2011;1(1):59-64.
31. Alagarsamy V, Narayanan V, Thangathirupathy R, Amuthalakshmi S, Sivakamisundari S, Jubie P, Syed Ali S, Suresh AKS, M. Anti-inflammatory activity of Dodonaea viscosa Linn leaf extracts. Indian Drugs. 2007;44(7):559-60.
32. Alagarsamy V, Amuthalakshmi S, Revathi R. Analgesic, anti-inflammatory and antibacterial activity of some novel 2-phenyl-3-(substituted methyl amino) quinazolin-4(3H)-ones. Indian J Pharm Sci. 2003;534-7.
33. Alagarsamy V, Amuthalakshmi S, Pathak US, Thirumurugan K. Anticancer, antibacterial and antifungal activities of some novel 2-substituted (1,3,4) thiodiazolo thieno(3,2-e) pyrimidin-5(4H)-ones. Indian J Heterocycl Chem. 2003;12:335-8.
34. Alagarsamy V, Rajasoloman V, Sivaperuman A, Revathi R. Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-phenyl-3-substituted quinazolin-4(3H)-ones. Biol Pharm Bull. 2002;25(11):1432-5.
• Published a book in LAP Lambert Academic Publications on Pharmaceutical Inorganic Chemistry Experimental Book for Pharm.D on 14/02/2024 (ISSN – 978-620-7-46561-3)
• Published a book in LAP Lambert Academic Publications on Experimental Book for Pharmaceutical organic Chemistry for B.Pharm. on 24/12/2025 (ISBN-10:6209493467)
Received an Indian patent on 13/02/2024 entitled “Preparation, Method and Uses of Amide Benzothiazole Derivatives for the Treatment of Diabetes” ( Inventors: S.Amuthalakshmi, A.Anton Smith Patent no: 510267).
1. Computational 2d-qsar-based drug design and in-silico evaluation of novel triazolidine derivatives as alpha glucosidase inhibitors Krithuka S, Amuthalakshmi S, Vijayakumari S, Yuvasree K, Nithyadharshini S 16/02/26 & 17/02/26 International conference on Recent Advances in Pharmaceutical Research – Industrial perspective held on B.S.Abdur Rahman Crescent Institute of Science & Technology GST Road, Vandalur, Chennai 600 048
2. Identification Of oxadiazole Leads For Anti-Alzheimer’s Activity By Insilico Studies Swetha. S, S.Amuthalakshmi 07/02/2025 & 08/02/2025 JSS college of Pharmacy, OOTY
3. Identification Neuroprotective Leads For Anti-Alzheimer’s Activity By Insilico Studies Megha D, S.Amuthalakshmi 07/02/2025 & 08/02/2025 JSS college of Pharmacy, OOTY
4. 2D-QSAR, Docking and Insilico Analysis Of 4-Amino-Benzylpiperidine Derivates as Multi Target Anti-Alzheimer Agents Indrakumar S, Amuthalakshmi S, Murthish S, Ilyaseelan J J 5th to 7th July 2024 73rd IPC conference, Hyderabad
5. 2D-QSAR Modelling, In-Silico Screening, Docking, Synthesis, Characterization, In-Vitro Evaluation of Quinoxaline Derivatives as Anti-Parkinson’s Agent Dibenthiran S, Keerthana.D, Dr Amuthalakshmi.S 29th June 2024 Mohammed sathak college of pharmacy
6. 2D-QSAR Study, In-Silico Screening, Synthesis, Characterization and In-Vitro Evaluation of Coumarin-Oxadiazole Hybrids as Anti-Alzheimer’s Agents Indrakumar S, Prabakaran A, Amuthalakshmi S 29th June 2024 Mohammed sathak college of pharmacy
7. 2D-QSAR Study, In-Silico Screening, Synthesis, Characterization And In-Vitro Evaluation of Oxadiazole Bridged Hybrids as Anti-Alzheimer’s Agents Sathishkumar M, Prabakaran A, Amuthalakshmi S 23rd And 24th July 2024 Vistas, Pallavaram, Chennai
8. 2D-QSAR Modelling, In-Silico Screening, Docking, Synthesis, Characterization, In-Vitro Evaluation of bridged Quinoxaline Derivatives Pradeep. N*, Keerthana.D, Dr Amuthalakshmi.S 29th august 2024 CL. Baid Metha college of pharmacy
9. Identification Of Leads For Anti-Alzheimer’s Activity By Insilico Studies Nithyadarshini.R*, Murthish.S,Amuthalakshmi,Yuvashree.R 30th august 2024 CL. Baid Metha college of pharmacy
10. Identification of Potent Multi-Target Inhibitors for Alzheimer’s Activity By Insilico Studies Yuvasree R*, Amuthalakshmi, Keerthana D 29th august 2024 CL. Baid Metha college of pharmacy
11. 2D-QSAR, Docking and Insilico Analysis Of 4-Amino-Benzylpiperidine Derivates as Multi Target Anti-Alzheimer Agents Indrakumar S, Amuthalakshmi S, Murthish S, Ilyaseelan J J 5th to 7th July 2024 73rd IPC conference, Hyderabad
12. Sundari J, Sarath Kumar D, Amuthalakshmi S, Nalini CN, “RP-UPLC method development & validation for simultaneous estimation of mometasone furoate & miconazole nitrate in semisolid dosage form”, on 20-22nd December organized by the 71st Indian Pharmaceutical Congress, Chennai.
13. Kavitha M, Uma J, Amuthalakshmi S, Nalini CN, “Simultaneous estimation of Metronidazole Furazolidone and Dicyclomine by RP-HPLC in capsule dosage form Impact of Recent Policy Changes on Pharmaceutical Industries” on 01st and 02nd March 2019 organised by the JSS College Of Pharmacy, Ooty.
14. Sarathkumar D, Amuthalakshmi S, “Analytical method development and validation by RP-UPLC for estimation of Levosalbutamol Guaiphensin and Ambroxol in syrup QbD and Six Sigma in Pharma Sector-Tools Perspectives and Challenges” on 21 &22 nd June 2019 organised by the C.L.Baid Metha College of Pharmacy, Chennai.
15. Presented a paper on “Modeling Assisted Insilico Design of Ligand molecule for DPP IV in type 2 diabetes” in Trends in Pharmaceutical Sciences on 16th & 17th April 2012, organized by the Department of Pharmacy, Annamalai University, Annamalai Nagar.
16. Presented a paper on “Ligand molecule fortype 2 diabetes using Insilico design” in AICTE sponsored one day national seminar on recent trends in novel drug delivery systems on 4th October 2013, organized by Mother Therasa Post Graduate and Research Institute of Health Sciences, Puducherry.
17. Presented a paper on “Insilico Design of DPP IV Ligand in type 2 diabetes” in International Conference of Pharma Vision – Present & Future on 6th & 7th October 2012, organized by International Congress of Pharmacy Graduates in Chettinad Health City, Kelambakkam, Chennai.
18. Presented a paper on “Design of Ligand molecule for DPP IV in type 2 diabetes using modeling studies” in Seventh Indo-US Workshop on Mathemetical Chemistry on 4th-6th December 2012, organized by PRIST University, Thanjavur
19. Actively attended 70 national and international conferences related to the field of study as part of academic and professional development.
Received a Theme Based Research (TBR) Grant for April-June 2024 from The TNMGR Medical university by July 2024 in the title of “AI-Driven Virtual Screening: Uncovering novel poly pharmacological ligands targeting Alzheimer’s disease via Flavone-acridine/piperidine scaffolds” for 2 Lakh rupees.
Received an Indian patent on 13/02/2024 entitled “Preparation, Method and Uses of Amide Benzothiazole Derivatives for the Treatment of Diabetes” ( Inventors: S.Amuthalakshmi, A.Anton Smith Patent no: 510267).
Delivered a guest lecture on “Addressing Major Perspectives for the Prevention, Care, and Treatment of Viral Hepatitis” at Sathyabama School of Pharmacy on 28 July 2023.
Completed my Full-Time REGULAR Ph.D in ANNALAI UNIVERSITY under the UGC-BSR (SAP) Fellowship during the period of 2010-2014
Served as a Doctoral Committee Member and Advisory Committee Member for Ph.D. candidates during their public viva voce examinations at The Tamil Nadu Dr. M.G.R. Medical University.
Inspector, Question paper setter, valuator, practical examiner, and PG/Ph.D thesis evaluator for universities including Annamalai university, SRM, JSS, Sathhyabama and Abdul Kalam University.
Organized A National Conference Titled QBD and Six sigma In Pharma Sector – Tools,Perspectives and Challenges On 21 And 22 June 2019.
Acted as a potential reviewer for an e-book chapter “MR Spectroscopy in Neuroradiology” published by Bentham Science Publishers.
A potential reviewer for Various Manuscripts under Pharmacy Category for Publishers like Bentham, Web of Science Group Journals, Elseiver and Springer Journals .
Topper in NPTEL Medicinal Chemistry Exam with 87 percent marks.
Published a book in LAP Lambert Academic Publications on Pharmaceutical Inorganic Chemistry Experimental Book for Pharm.D on 14/02/2024 (ISSN – 978-620-7-46561-3)
Published a book in LAP Lambert Academic Publications on Experimental Book for Pharmaceutical organic Chemistry for B.Pharm. on 24/12/2025 (ISBN-10:6209493467)
Appointed as a Convenor/Member, Inspection Commission by The Tamilnadu Dr.M.G.R. Medical University,
Recognized as a Ph.D Guide for Guiding the Ph.D Candidates in The Tamilnadu Dr.M.G.R. Medical University